Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
نویسندگان
چکیده
منابع مشابه
Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK
Obesity is increasing rapidly worldwide and is accompanied by many complications, including impaired muscle regeneration. The obese condition is known to inhibit AMPK activity in multiple tissues. We hypothesized that the loss of AMPK activity is a major reason for hampered muscle regeneration in obese subjects. We found that obesity inhibits AMPK activity in regenerating muscle, which was asso...
متن کاملAMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.
Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPKα1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPKα1(-/-) mice. In vivo loss-of-function (LysM-Cre;AMPKα...
متن کاملAnnexin A1 Induces Skeletal Muscle Cell Migration Acting through Formyl Peptide Receptors
Annexin A1 (ANXA1, lipocortin-1) is a glucocorticoid-regulated 37-kDa protein, so called since its main property is to bind (i.e. to annex) to cellular membranes in a Ca(2+)-dependent manner. Although ANXA1 has predominantly been studied in the context of immune responses and cancer, the protein can affect a larger variety of biological phenomena, including cell proliferation and migration. Our...
متن کاملAnnexin A1 can inhibit the in vitro invasive ability of nasopharyngeal carcinoma cells possibly through Annexin A1/S100A9/Vimentin interaction
Annexin A1 is a member of a large superfamily of glucocorticoid-regulated, calcium- and phospholipid-binding proteins. Our previous studies have shown that the abnormal expression of Annexin A1 is related to the occurrence and development of nasopharyngeal carcinoma (NPC). To understand the roles of Annexin A1 in the tumorigenesis of NPC, targeted proteomic analysis was performed on Annexin A1-...
متن کاملCell Metabolism AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
Manuscript Number: CELL-METABOLISM-D-13-00308R2 Full Title: AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration Article Type: Research Article
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci124635